Nature of Lupron
Lupron (leuprolide acetate) Injection is a long-acting analog of
the naturally occurring hormone GnRH made by TAP Pharmaceuticals.
Analogs are chemical compounds with a similar structure to another
compound or substance but differs in respect to a "certain
component." This "certain component" change gives
the analog a similar or opposite action to the native compound or
is an abbreviation for "gonadotropin releasing hormone."
This hormone is produced in the brain by the hypothalamus and is
the regulator of gonadotropins, FSH (follicle stimulating hormone)
and LH (luteinizing hormone). FSH stimulates estrogen production
from follicles on the surface of the ovaries. LH helps trigger ovulation
and release of eggs.
acting GnRH analogs have potential therapeutic value for the treatment
of patients with a variety of diseases. It has been approved by
the FDA (food and drug administration) for the treatment of men
with metastatic prostate cancer. It has also been approved for the
treatment of women with endometriosis and uterine fibroids. It is
currently under extensive investigation for many other hormonally
dependent conditions related to women.
those conditions shown to have benefited from Depot Lupron administration
are leiomyomata uteri (fibroid uterus), endometriosis, excessive
hair growth (hirsutism), breast cancer, and menstrual disorders
caused by ovulatory dysfunction (PMS, precocious puberty, irregular
cycles, etc.). For this reason, this information is intended to
help inform you about this medication.
Potential Benefits of Lupron
have been chosen to consider the use of Depot Lupron because of
your particular problem. With regard to endometriosis and fibroids,
this drug has been shown to improve the adverse effects of these
hormonally dependent conditions by lowering estrogen levels produced
by the ovaries.
does this by inhibiting gonadotropin secretion when given continuously.
By giving you a monthly injection of Depot Lupron, a decrease in
the level of your own FSH and LH will occur. This action then allows
us to suppress growth and function of these types of diseases yielding
you a better chance to accomplish your desired goal. This effect
is reversible upon discontinuation of drug therapy. Spontaneous
ovulatory cycles can usually be expected to resume within 4?6 weeks
after discontinuation of Lupron.
Lupron is not active when taken orally. Because of this, it must
be administered monthly by intramuscular injection of 3.75 milligrams.
Another dose of 11.25 milligrams lasts for 3 months. During the
duration of its use, you will be monitored by pelvic examinations,
hormonal blood tests, or by pelvic ultrasounds to assess your own
response to the drug if there is question as to its effectiveness.
This testing allows us to use the right amount of drug for your
particular case with safety and to attain its maximum benefit.
Lupron Risks and/or Side Effects
Lupron has not been shown to cause major long- or short-term side
effects in humans. It is rapidly transformed into inactive compounds
by the body. The risks of therapy include: 1) failure of the drug
to work in your particular condition, 2) occurrence of hot flashes
and headaches while on the drug, 3) discontinuation of cyclic menstrual
cycles while on the drug, 4) a local skin reaction (rash) at the
injection site, and 5) a slight delay (4?6 weeks) in resumption
of subsequent cycles after discontinuation of the drug. Initiation
of oral contraceptives prior to giving a patient Depot Lupron often
diminishes the side effects of low estrogen caused by the drug.
It also helps to prevent long-term sequelae of low estrogen states
if the patient is on Lupron for more than 3 months.
Alternative Therapy to Lupron
therapies should always be discussed prior to initiation of any
drug. With regard to fibroids and pelvic endometriosis, alternatives
include observation, other drug therapy (i.e., danocrine, oral contraceptives,
progestins, etc.) and surgery. Please go over these alternatives
with your physician.